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Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis

Infection with cagA-positive Helicobacter pylori is critically associated with the development of gastric cancer. The cagA-encoded CagA is delivered into gastric epithelial cells via type IV secretion, where it interacts with and thereby deregulates the pro-oncogenic phosphatase SHP2. East Asian Cag...

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Detalles Bibliográficos
Autores principales:	Nagase, Lisa, Hayashi, Takeru, Senda, Toshiya, Hatakeyama, Masanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623810/ https://www.ncbi.nlm.nih.gov/pubmed/26507409 http://dx.doi.org/10.1038/srep15749

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