Thymidylate synthase expression as a predictive biomarker of pemetrexed sensitivity in advanced non-small cell lung cancer

BACKGROUND: Although it has been suggested that a high level of thymidylate synthase (TYMS) gene expression in malignant tumors is related to reduced sensitivity to the antifolate drug pemetrexed, no direct evidence for such an association has been demonstrated in routine clinical samples from patie...

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Detalles Bibliográficos
Autores principales: Chamizo, Cristina, Zazo, Sandra, Dómine, Manuel, Cristóbal, Ion, García-Foncillas, Jesús, Rojo, Federico, Madoz-Gúrpide, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623912/
https://www.ncbi.nlm.nih.gov/pubmed/26502926
http://dx.doi.org/10.1186/s12890-015-0132-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623912/
https://www.ncbi.nlm.nih.gov/pubmed/26502926
http://dx.doi.org/10.1186/s12890-015-0132-x

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