Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

BACKGROUND: Undifferentiated pleomorphic sarcoma (UPS) is a heterogeneous tumor group, and little is known about molecular target therapy for UPS. Heat shock protein 90 (HSP90) is an expressed chaperone that refolds certain denatured proteins under stress conditions. One of these proteins is Akt. Th...

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Detalles Bibliográficos
Autores principales: Bekki, Hirofumi, Kohashi, Kenichi, Maekawa, Akira, Yamada, Yuichi, Yamamoto, Hidetaka, Harimaya, Katsumi, Hakozaki, Michiyuki, Nabeshima, Kazuki, Iwamoto, Yukihide, Oda, Yoshinao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623920/
https://www.ncbi.nlm.nih.gov/pubmed/26502919
http://dx.doi.org/10.1186/s12885-015-1830-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623920/
https://www.ncbi.nlm.nih.gov/pubmed/26502919
http://dx.doi.org/10.1186/s12885-015-1830-8

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