Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis resulting in B-cell lymphoma

Many human tumors express high levels of the p53 inhibitor Mdm2, resulting from amplification of the Mdm2 locus or aberrant post-translational regulation of the Mdm2 protein. While the importance of Mdm2 in regulating p53 is clear, Mdm2 also has p53-independent roles. For example, overexpression of...

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Detalles Bibliográficos
Autores principales: Riley, Maurisa F., You, M. James, Multani, Asha S., Lozano, Guillermina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624041/
https://www.ncbi.nlm.nih.gov/pubmed/25915849
http://dx.doi.org/10.1038/onc.2015.88

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624041/
https://www.ncbi.nlm.nih.gov/pubmed/25915849
http://dx.doi.org/10.1038/onc.2015.88

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