Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease

Machado-Joseph disease (MJD) is an inherited neurodegenerative disease, caused by a CAG repeat expansion within the coding region of ATXN3 gene, and which currently lacks effective treatment. In this work we tested the therapeutic efficacy of chronic treatment with valproic acid (VPA) (200mg/kg), a...

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Detalles Bibliográficos
Autores principales: Esteves, Sofia, Duarte-Silva, Sara, Naia, Luana, Neves-Carvalho, Andreia, Teixeira-Castro, Andreia, Rego, Ana Cristina, Silva-Fernandes, Anabela, Maciel, Patrícia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624233/
https://www.ncbi.nlm.nih.gov/pubmed/26505994
http://dx.doi.org/10.1371/journal.pone.0141610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624233/
https://www.ncbi.nlm.nih.gov/pubmed/26505994
http://dx.doi.org/10.1371/journal.pone.0141610

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