E2-EPF UCP regulates stability and functions of missense mutant pVHL via ubiquitin mediated proteolysis

BACKGROUND: Missense mutation of VHL gene is frequently detected in type 2 VHL diseases and linked to a wide range of pVHL functions and stability. Certain mutant pVHLs retain ability to regulate HIFs but lose their function by instability. In this case, regulating of degradation of mutant pVHLs, ca...

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Detalles Bibliográficos
Autores principales: Park, Kyeong-Su, Kim, Ju Hee, Shin, Hee Won, Chung, Kyung-Sook, Im, Dong-Soo, Lim, Jung Hwa, Jung, Cho-Rok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624580/
https://www.ncbi.nlm.nih.gov/pubmed/26503325
http://dx.doi.org/10.1186/s12885-015-1786-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624580/
https://www.ncbi.nlm.nih.gov/pubmed/26503325
http://dx.doi.org/10.1186/s12885-015-1786-8

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