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E2-EPF UCP regulates stability and functions of missense mutant pVHL via ubiquitin mediated proteolysis
BACKGROUND: Missense mutation of VHL gene is frequently detected in type 2 VHL diseases and linked to a wide range of pVHL functions and stability. Certain mutant pVHLs retain ability to regulate HIFs but lose their function by instability. In this case, regulating of degradation of mutant pVHLs, ca...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624580/ https://www.ncbi.nlm.nih.gov/pubmed/26503325 http://dx.doi.org/10.1186/s12885-015-1786-8 |