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Dysfunctional Presynaptic M(2) Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse
The muscarinic M(2) receptor (M2R) acts as a negative feedback regulator in central cholinergic systems. Activation of the M(2) receptor limits acetylcholine (ACh) release, especially when ACh levels are increased because acetylcholinesterase (AChE) activity is acutely inhibited. Chronically high AC...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624712/ https://www.ncbi.nlm.nih.gov/pubmed/26506622 http://dx.doi.org/10.1371/journal.pone.0141136 |