Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma

PURPOSE: To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. METHODS: We produced IOP increase in CD1 mice and performed unilateral optic nerve crush. Mice received oral losartan, spironolactone,...

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Detalles Bibliográficos
Autores principales: Quigley, Harry A., Pitha, Ian F., Welsbie, Derek S., Nguyen, Cathy, Steinhart, Matthew R., Nguyen, Thao D., Pease, Mary Ellen, Oglesby, Ericka N., Berlinicke, Cynthia A., Mitchell, Katherine L., Kim, Jessica, Jefferys, Joan J., Kimball, Elizabeth C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624713/
https://www.ncbi.nlm.nih.gov/pubmed/26505191
http://dx.doi.org/10.1371/journal.pone.0141137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624713/
https://www.ncbi.nlm.nih.gov/pubmed/26505191
http://dx.doi.org/10.1371/journal.pone.0141137

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