Cargando…

Apelin-13 protects the heart against ischemia-reperfusion injury through the RISK-GSK-3β-mPTP pathway

INTRODUCTION: Apelin plays an important role in the protection against myocardial ischemia-reperfusion (I/R) injury, while the mechanism still remains unclear. In the current study, we aimed to evaluate the protective effect of apelin-13, and the main mechanism. MATERIAL AND METHODS: The in vivo I/R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Shuansuo, Li, Hui, Tang, Lei, Ge, Guanghao, Ma, Jiangwei, Qiao, Zengyong, Liu, Huajin, Fang, Weiyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Termedia Publishing House 2015
Materias:	Basic Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624751/ https://www.ncbi.nlm.nih.gov/pubmed/26528352 http://dx.doi.org/10.5114/aoms.2015.54863

Ejemplares similares

Evaluation of the Antioxidant Potential of Salvia miltiorrhiza Ethanol Extract in a Rat Model of Ischemia-Reperfusion Injury
por: Qiao, Zengyong, et al.
Publicado: (2011)

Effect of Ligusticum wallichii Aqueous Extract on Oxidative Injury and Immunity Activity in Myocardial Ischemic Reperfusion Rats
por: Zengyong, Qiao, et al.
Publicado: (2011)

ARC regulates programmed necrosis and myocardial ischemia/reperfusion injury through the inhibition of mPTP opening
por: Xu, Tao, et al.
Publicado: (2018)

Protective effect of curcumin against myocardium injury in ischemia reperfusion rats
por: Liu, HuaJin, et al.
Publicado: (2017)

Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury
por: Shao, Zi-Qi, et al.
Publicado: (2020)

Sirt3 targets mPTP and prevents aging in the heart
por: Sadoshima, Junichi
Publicado: (2011)

Diabetes Worsens Ischemia-Reperfusion Brain Injury in Rats Through GSK-3β
por: Liu, Hua, et al.
Publicado: (2015)

Attenuation of Skeletal Muscle and Renal Injury to the Lower Limb following Ischemia-Reperfusion Using mPTP Inhibitor NIM-811
por: Garbaisz, David, et al.
Publicado: (2014)

Cryptotanshinone Ameliorates Doxorubicin-Induced Cardiotoxicity by Targeting Akt-GSK-3β-mPTP Pathway In Vitro
por: Wang, Xiaoping, et al.
Publicado: (2021)

Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury
por: Yan, Xiao-ge, et al.
Publicado: (2015)

Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats
por: Zhang, Li, et al.
Publicado: (2012)

HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation
por: Mancardi, Daniele, et al.
Publicado: (2022)

3579 The role of CypD/mPTP during osteogenic differentiation - a potential target to prevent bone loss
por: Sautchuk, Rubens, et al.
Publicado: (2019)

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission‐VDAC1‐HK2‐mPTP‐mitophagy axis
por: Zhou, Hao, et al.
Publicado: (2017)

Akt-GSK3β-mPTP pathway regulates the mitochondrial dysfunction contributing to odontoblasts apoptosis induced by glucose oxidative stress
por: Wu, Danni, et al.
Publicado: (2022)

SALVIANOLIC ACID B ALLEVIATING MYOCARDIUM INJURY IN ISCHEMIA REPERFUSION RATS
por: Qiao, Zengyong, et al.
Publicado: (2016)

EP4 activation ameliorates liver ischemia/reperfusion injury via ERK1/2-GSK3β-dependent MPTP inhibition
por: Cai, Lin-Lin, et al.
Publicado: (2020)

Experimental Study on the Role of Apelin-13 in Alleviating Spinal Cord Ischemia Reperfusion Injury Through Suppressing Autophagy
por: Xu, Zhewei, et al.
Publicado: (2020)

Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues
por: Wang, Wang, et al.
Publicado: (2013)

SERCA overexpression reduces reperfusion-mediated cardiac microvascular damage through inhibition of the calcium/MCU/mPTP/necroptosis signaling pathways
por: Li, Chen, et al.
Publicado: (2020)

Mitochondrial DNA Efflux Maintained in Gingival Fibroblasts of Patients with Periodontitis through ROS/mPTP Pathway
por: Liu, Jia, et al.
Publicado: (2022)

Apelin receptor inhibition in ischemia-reperfused mouse hearts protected by endogenous n-3 polyunsaturated fatty acids
por: Zheng, Shuang, et al.
Publicado: (2023)

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling
por: Duan, Jialin, et al.
Publicado: (2019)

Serum Apelin and Obesity-Related Complications in Egyptian Children
por: El Wakeel, Maged A., et al.
Publicado: (2018)

Effect of the CRAC Peptide, VLNYYVW, on mPTP Opening in Rat Brain and Liver Mitochondria
por: Azarashvili, Tamara, et al.
Publicado: (2016)

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells
por: Teixeira, José, et al.
Publicado: (2017)

Identification of Phosphorylated Calpain 3 in Rat Brain Mitochondria under mPTP Opening
por: Baburuna, Yulia, et al.
Publicado: (2021)

Promising Strategy of mPTP Modulation in Cancer Therapy: An Emerging Progress and Future Insight
por: Waseem, Mohammad, et al.
Publicado: (2023)

Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells
por: Zhang, Rong, et al.
Publicado: (2018)

High-throughput sequencing analysis of differentially expressed miRNAs and target genes in ischemia/reperfusion injury and apelin-13 neuroprotection
por: Wang, Chun-mei, et al.
Publicado: (2018)

Ischemia/reperfusion injury in porcine intestine - Viability assessment
por: Strand-Amundsen, Runar J, et al.
Publicado: (2018)

Effects of Urtica dioica on hepatic ischemia‐reperfusion injury in rats
por: Kandis, Hayati, et al.
Publicado: (2010)

Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury
por: Nakayama, Yosuke, et al.
Publicado: (2014)

Neuroprotective effect of atorvastatin in spinal cord ischemia-reperfusion injury
por: Nazli, Yunus, et al.
Publicado: (2015)

Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury
por: Takasu, Chie, et al.
Publicado: (2017)

Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
por: Ferko, Miroslav, et al.
Publicado: (2019)

Activation of Nrf2 Signaling by Apelin Attenuates Renal Ischemia Reperfusion Injury in Diabetic Rats
por: Zhang, Xiaobo, et al.
Publicado: (2020)

Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion
por: Pisarenko, O. I., et al.
Publicado: (2014)

S-Nitroso-N-Acetylcysteine Ameliorates Ischemia-Reperfusion Injury In The Steatotic Liver
por: Andraus, Wellington, et al.
Publicado: (2010)

Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats
por: Kim, Joohyun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vv3ip60sha35o9744e9k5cqfvr