Evaluation of optimized bronchoalveolar lavage sampling designs for characterization of pulmonary drug distribution

Bronchoalveolar lavage (BAL) is a pulmonary sampling technique for characterization of drug concentrations in epithelial lining fluid and alveolar cells. Two hypothetical drugs with different pulmonary distribution rates (fast and slow) were considered. An optimized BAL sampling design was generated...

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Detalles Bibliográficos
Autores principales: Clewe, Oskar, Karlsson, Mats O., Simonsson, Ulrika S. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624821/
https://www.ncbi.nlm.nih.gov/pubmed/26316105
http://dx.doi.org/10.1007/s10928-015-9438-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624821/
https://www.ncbi.nlm.nih.gov/pubmed/26316105
http://dx.doi.org/10.1007/s10928-015-9438-9

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