Inter occasion variability in individual optimal design

Inter occasion variability (IOV) is of importance to consider in the development of a design where individual pharmacokinetic or pharmacodynamic parameters are of interest. IOV may adversely affect the precision of maximum a posteriori (MAP) estimated individual parameters, yet the influence of incl...

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Detalles Bibliográficos
Autores principales: Kristoffersson, Anders N., Friberg, Lena E., Nyberg, Joakim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624834/
https://www.ncbi.nlm.nih.gov/pubmed/26452548
http://dx.doi.org/10.1007/s10928-015-9449-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624834/
https://www.ncbi.nlm.nih.gov/pubmed/26452548
http://dx.doi.org/10.1007/s10928-015-9449-6

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