The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness

FLT3 and c-KIT are crucial regulators of hematopoietic stem and progenitor cells. We investigated the role of STS1 and STS2 on FLT3 and c-KIT phosphorylation, activity, and function in normal and stress-induced hematopoiesis. STS1/STS2-deficient mice show a profound expansion of multipotent progenit...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Vakhrusheva, Olesya, Bandi, Srinivasa Rao, Demirel, Özlem, Kazi, Julhash U., Fernandes, Ramona Gomes, Jakobi, Katja, Eichler, Astrid, Rönnstrand, Lars, Rieger, Michael A., Carpino, Nick, Serve, Hubert, Brandts, Christian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624938/
https://www.ncbi.nlm.nih.gov/pubmed/26365512
http://dx.doi.org/10.1016/j.stemcr.2015.08.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624938/
https://www.ncbi.nlm.nih.gov/pubmed/26365512
http://dx.doi.org/10.1016/j.stemcr.2015.08.006

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