Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals

Chromosome abnormalities are common in the human population, causing germ cell loss at meiotic prophase I and infertility. The mechanisms driving this loss are unknown, but persistent meiotic DNA damage and asynapsis may be triggers. Here we investigate the contribution of these lesions to oocyte el...

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Detalles Bibliográficos
Autores principales: Cloutier, Jeffrey M., Mahadevaiah, Shantha K., ElInati, Elias, Nussenzweig, André, Tóth, Attila, Turner, James M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624946/
https://www.ncbi.nlm.nih.gov/pubmed/26509888
http://dx.doi.org/10.1371/journal.pgen.1005462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624946/
https://www.ncbi.nlm.nih.gov/pubmed/26509888
http://dx.doi.org/10.1371/journal.pgen.1005462

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