Linagliptin Limits High Glucose Induced Conversion of Latent to Active TGFß through Interaction with CIM6PR and Limits Renal Tubulointerstitial Fibronectin

BACKGROUND: In addition to lowering blood glucose in patients with type 2 diabetes mellitus, dipeptidyl peptidase 4 (DPP4) inhibitors have been shown to be antifibrotic. We have previously shown that cation independent mannose-6-phosphate receptor (CIM6PR) facilitates the conversion of latent to act...

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Detalles Bibliográficos
Autores principales: Gangadharan Komala, Muralikrishna, Gross, Simon, Zaky, Amgad, Pollock, Carol, Panchapakesan, Usha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624988/
https://www.ncbi.nlm.nih.gov/pubmed/26509887
http://dx.doi.org/10.1371/journal.pone.0141143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624988/
https://www.ncbi.nlm.nih.gov/pubmed/26509887
http://dx.doi.org/10.1371/journal.pone.0141143

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