Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function

The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine densit...

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Detalles Bibliográficos
Autores principales: Barucker, Christian, Bittner, Heiko J., Chang, Philip K.-Y., Cameron, Scott, Hancock, Mark A., Liebsch, Filip, Hossain, Shireen, Harmeier, Anja, Shaw, Hunter, Charron, François M., Gensler, Manuel, Dembny, Paul, Zhuang, Wei, Schmitz, Dietmar, Rabe, Jürgen P., Rao, Yong, Lurz, Rudi, Hildebrand, Peter W., McKinney, R. Anne, Multhaup, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625140/
https://www.ncbi.nlm.nih.gov/pubmed/26510576
http://dx.doi.org/10.1038/srep15410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625140/
https://www.ncbi.nlm.nih.gov/pubmed/26510576
http://dx.doi.org/10.1038/srep15410

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