Generation of a miniature pig disease model for human Laron syndrome

Laron syndrome is a rare disease caused by mutations of the growth hormone receptor (GHR), inheriting in an autosomal manner. To better understand the pathogenesis and to develop therapeutics, we generated a miniature pig model for this disease by employing ZFNs to knock out GHR gene. Three types of...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Dan, Li, Fang, Li, Qiuyan, Li, Jia, Zhao, Yaofeng, Hu, Xiaoxiang, Zhang, Ran, Li, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625145/
https://www.ncbi.nlm.nih.gov/pubmed/26511035
http://dx.doi.org/10.1038/srep15603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625145/
https://www.ncbi.nlm.nih.gov/pubmed/26511035
http://dx.doi.org/10.1038/srep15603

Ejemplares similares