Structural evidence for the role of polar core residue Arg175 in arrestin activation

Binding mechanism of arrestin requires photoactivation and phosphorylation of the receptor protein rhodopsin, where the receptor bound phosphate groups cause displacement of the long C-tail ‘activating’ arrestin. Mutation of arginine 175 to glutamic acid (R175E), a central residue in the polar core...

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Detalles Bibliográficos
Autores principales: Granzin, Joachim, Stadler, Andreas, Cousin, Anneliese, Schlesinger, Ramona, Batra-Safferling, Renu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625158/
https://www.ncbi.nlm.nih.gov/pubmed/26510463
http://dx.doi.org/10.1038/srep15808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625158/
https://www.ncbi.nlm.nih.gov/pubmed/26510463
http://dx.doi.org/10.1038/srep15808

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