Development of a Multicompartment Permeability-Limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs

Achieving sufficient concentrations of antituberculosis (TB) drugs in pulmonary tissue at the optimum time is still a challenge in developing therapeutic regimens for TB. A physiologically based pharmacokinetic model incorporating a multicompartment permeability-limited lung model was developed and...

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Detalles Bibliográficos
Autores principales: Gaohua, L, Wedagedera, J, Small, BG, Almond, L, Romero, K, Hermann, D, Hanna, D, Jamei, M, Gardner, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625865/
https://www.ncbi.nlm.nih.gov/pubmed/26535161
http://dx.doi.org/10.1002/psp4.12034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625865/
https://www.ncbi.nlm.nih.gov/pubmed/26535161
http://dx.doi.org/10.1002/psp4.12034

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