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Robust and efficient parameter estimation in dynamic models of biological systems
BACKGROUND: Dynamic modelling provides a systematic framework to understand function in biological systems. Parameter estimation in nonlinear dynamic models remains a very challenging inverse problem due to its nonconvexity and ill-conditioning. Associated issues like overfitting and local solutions...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625902/ https://www.ncbi.nlm.nih.gov/pubmed/26515482 http://dx.doi.org/10.1186/s12918-015-0219-2 |