Small-molecule agonists of mammalian Diaphanous–related (mDia) formins reveal an effective glioblastoma anti-invasion strategy

The extensive invasive capacity of glioblastoma (GBM) makes it resistant to surgery, radiotherapy, and chemotherapy and thus makes it lethal. In vivo, GBM invasion is mediated by Rho GTPases through unidentified downstream effectors. Mammalian Diaphanous (mDia) family formins are Rho-directed effect...

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Detalles Bibliográficos
Autores principales: Arden, Jessica D., Lavik, Kari I., Rubinic, Kaitlin A., Chiaia, Nicolas, Khuder, Sadik A., Howard, Marthe J., Nestor-Kalinoski, Andrea L., Alberts, Arthur S., Eisenmann, Kathryn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626057/
https://www.ncbi.nlm.nih.gov/pubmed/26354425
http://dx.doi.org/10.1091/mbc.E14-11-1502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626057/
https://www.ncbi.nlm.nih.gov/pubmed/26354425
http://dx.doi.org/10.1091/mbc.E14-11-1502

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