Cargando…

Small-molecule agonists of mammalian Diaphanous–related (mDia) formins reveal an effective glioblastoma anti-invasion strategy

The extensive invasive capacity of glioblastoma (GBM) makes it resistant to surgery, radiotherapy, and chemotherapy and thus makes it lethal. In vivo, GBM invasion is mediated by Rho GTPases through unidentified downstream effectors. Mammalian Diaphanous (mDia) family formins are Rho-directed effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arden, Jessica D., Lavik, Kari I., Rubinic, Kaitlin A., Chiaia, Nicolas, Khuder, Sadik A., Howard, Marthe J., Nestor-Kalinoski, Andrea L., Alberts, Arthur S., Eisenmann, Kathryn M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626057/ https://www.ncbi.nlm.nih.gov/pubmed/26354425 http://dx.doi.org/10.1091/mbc.E14-11-1502

Ejemplares similares

Carcinoma associated fibroblasts (CAFs) promote breast cancer motility by suppressing mammalian Diaphanous-related formin-2 (mDia2)
por: Dvorak, Kaitlyn M., et al.
Publicado: (2018)

Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish
por: LeCorgne, Hunter, et al.
Publicado: (2018)

Diaphanous formin mDia2 regulates CENP-A levels at centromeres
por: Liu, Chenshu, et al.
Publicado: (2016)

Loss of RhoB Expression Enhances the Myelodysplastic Phenotype of Mammalian Diaphanous-Related Formin mDia1 Knockout Mice
por: DeWard, Aaron D., et al.
Publicado: (2009)

The Cytoskeleton Effectors Rho-Kinase (ROCK) and Mammalian Diaphanous-Related (mDia) Formin Have Dynamic Roles in Tumor Microtube Formation in Invasive Glioblastoma Cells
por: Becker, Kathryn N., et al.
Publicado: (2022)

Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin
por: Mizuno, Hiroaki, et al.
Publicado: (2018)

Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLα and mDia1
por: Seth, Abhinav, et al.
Publicado: (2006)

Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
por: Mei, Yang, et al.
Publicado: (2020)

Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules
por: Gaillard, Jeremie, et al.
Publicado: (2011)

Crystal Structure of a Complex between Amino and Carboxy Terminal Fragments of mDia1: Insights into Autoinhibition of Diaphanous-Related Formins
por: Nezami, Azin, et al.
Publicado: (2010)

Dia-Interacting Protein (DIP) Imposes Migratory Plasticity in mDia2-Dependent Tumor Cells in Three-Dimensional Matrices
por: Wyse, Meghan M., et al.
Publicado: (2012)

Crystal Structure of the Formin mDia1 in Autoinhibited Conformation
por: Otomo, Takanori, et al.
Publicado: (2010)

mDia1 and formins: screw cap of the actin filament
por: Mizuno, Hiroaki, et al.
Publicado: (2012)

Formin’ cellular structures: Physiological roles of Diaphanous (Dia) in actin dynamics
por: Bogdan, Sven, et al.
Publicado: (2014)

Targeting the mDia Formin-Assembled Cytoskeleton Is an Effective Anti-Invasion Strategy in Adult High-Grade Glioma Patient-Derived Neurospheres
por: Pettee, Krista M., et al.
Publicado: (2019)

An mDia2/ROCK Signaling Axis Regulates Invasive Egress from Epithelial Ovarian Cancer Spheroids
por: Pettee, Krista M., et al.
Publicado: (2014)

Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments
por: Meiring, Joyce C. M., et al.
Publicado: (2019)

Geometrical Constraints Greatly Hinder Formin mDia1 Activity
por: Suzuki, Emiko L., et al.
Publicado: (2019)

Flightless-I (Fli-I) Regulates the Actin Assembly Activity of Diaphanous-related Formins (DRFs) Daam1 and mDia1 in Cooperation with Active Rho GTPase
por: Higashi, Tomohito, et al.
Publicado: (2010)

mDia1-3 in mammalian filopodia
por: Goh, Wah Ing, et al.
Publicado: (2012)

Novel Roles of Formin mDia2 in Lamellipodia and Filopodia Formation in Motile Cells
por: Yang, Changsong, et al.
Publicado: (2007)

The formin mDia2 stabilizes microtubules independently of its actin nucleation activity
por: Bartolini, Francesca, et al.
Publicado: (2008)

Proteomic Analyses Uncover a New Function and Mode of Action for Mouse Homolog of Diaphanous 2 (mDia2)
por: Isogai, Tadamoto, et al.
Publicado: (2015)

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1
por: Okada, Kyoko, et al.
Publicado: (2010)

Neuronal drebrin A directly interacts with mDia2 formin to inhibit actin assembly
por: Ginosyan, Anush A., et al.
Publicado: (2019)

The Formin mDia1 Regulates Acute Lymphoblastic Leukemia Engraftment, Migration, and Progression in vivo
por: Thompson, Scott B., et al.
Publicado: (2018)

Formin Activity and mDia1 Contribute to Maintain Axon Initial Segment Composition and Structure
por: Zhang, Wei, et al.
Publicado: (2021)

Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains
por: Gorelik, Roman, et al.
Publicado: (2011)

Apical targeting of the formin Diaphanous in Drosophila tubular epithelia
por: Rousso, Tal, et al.
Publicado: (2013)

Role of Cytoskeletal Diaphanous-Related Formins in Hearing Loss
por: Chiereghin, Chiara, et al.
Publicado: (2022)

Mammalian Diaphanous-Related Formin 1 Regulates GSK3β-Dependent Microtubule Dynamics Required for T Cell Migratory Polarization
por: Dong, Baoxia, et al.
Publicado: (2013)

Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2
por: Li, Xuehui, et al.
Publicado: (2017)

Direct observation of the conformational states of formin mDia1 at actin filament barbed ends and along the filament
por: Maufront, Julien, et al.
Publicado: (2022)

Characterization of Diaphanous-related formin FMNL2 in human tissues
por: Gardberg, Maria, et al.
Publicado: (2010)

The Formin Protein mDia2 Serves as a Marker of Spindle Pole Dynamics in Vitrified-Warmed Mouse Oocytes
por: Shin, Hyejin, et al.
Publicado: (2013)

Novel localization of formin mDia2: importin β-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope
por: Shao, Xiaowei, et al.
Publicado: (2015)

An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells
por: Bartolini, Francesca, et al.
Publicado: (2016)

Correction for An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells
Publicado: (2017)

Diaphanous-Related Formin 2 and Profilin I Are Required for Gastrulation Cell Movements
por: Lai, Shih-Lei, et al.
Publicado: (2008)

Enteropathogenic E. coli relies on collaboration between the formin mDia1 and the Arp2/3 complex for actin pedestal biogenesis and maintenance
por: Velle, Katrina B., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t9tm8it5c8qopcp9alclpjedg2