Cargando…
Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL–p97 complex
The initial folding of secreted proteins occurs in the ER lumen, which contains specific chaperones and where posttranslational modifications may occur. Therefore lack of translocation, regardless of entry route or protein identity, is a highly toxic event, as the newly synthesized polypeptide is mi...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626058/ https://www.ncbi.nlm.nih.gov/pubmed/26337389 http://dx.doi.org/10.1091/mbc.E15-02-0085 |