Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer's disease via mammalian target of rapamycin-dependent and -independent pathways

Memantine non-competitively blocks the N-methyl-d-aspartate receptor in order to inhibit beta-amyloid (Aβ) secretion, and has been used to treat moderate-to-severe Alzheimer's disease (AD). However, the mechanisms underlying the role of memantine in the autophagy and apoptosis of neuronal cells...

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Detalles Bibliográficos
Autores principales: SONG, GUIJUN, LI, YU, LIN, LULU, CAO, YUNPENG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626184/
https://www.ncbi.nlm.nih.gov/pubmed/26459718
http://dx.doi.org/10.3892/mmr.2015.4382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626184/
https://www.ncbi.nlm.nih.gov/pubmed/26459718
http://dx.doi.org/10.3892/mmr.2015.4382

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