RNAi-mediated knockdown of the CLN3 gene inhibits proliferation and promotes apoptosis in drug-resistant ovarian cancer cells

CLN3 is a recently identified anti-apoptotic gene, which has been demonstrated to be highly expressed in a diverse range of cancer cell lines, including ovarian cancer. In the present study, RNA interference, mediated by a lentivirus expressing CLN3 short hairpin RNA (shRNA) was utilized to knockdow...

Descripción completa

Detalles Bibliográficos
Autores principales: MAO, DONGWEI, CHE, JIANHUA, HAN, SHIYU, ZHAO, HONGHUI, ZHU, YUMEI, ZHU, HONG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626189/
https://www.ncbi.nlm.nih.gov/pubmed/26299671
http://dx.doi.org/10.3892/mmr.2015.4238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626189/
https://www.ncbi.nlm.nih.gov/pubmed/26299671
http://dx.doi.org/10.3892/mmr.2015.4238

Ejemplares similares