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Selective Phosphodiesterase Inhibitors for Psoriasis: Focus on Apremilast
Phosphodiesterase (PDE) 4 participates in regulating the inflammatory response by degrading cyclic adenosine 3′,5′-monophosphate (cAMP), a key second messenger. Inhibition of PDE4 increases the intracellular cAMP level, which in turn results in a reduction in inflammatory mediators and an increase i...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626529/ https://www.ncbi.nlm.nih.gov/pubmed/26481941 http://dx.doi.org/10.1007/s40259-015-0144-3 |