Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M pha...

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Detalles Bibliográficos
Autores principales: Mori, Shogo, Williams, Howard, Cagle, Davey, Karanovich, Kristopher, Horgen, F. David, Smith, Roger, Watanabe, Coran M. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626689/
https://www.ncbi.nlm.nih.gov/pubmed/26473885
http://dx.doi.org/10.3390/md13106274
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author Mori, Shogo
Williams, Howard
Cagle, Davey
Karanovich, Kristopher
Horgen, F. David
Smith, Roger
Watanabe, Coran M. H.
author_facet Mori, Shogo
Williams, Howard
Cagle, Davey
Karanovich, Kristopher
Horgen, F. David
Smith, Roger
Watanabe, Coran M. H.
author_sort Mori, Shogo
collection PubMed
description A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.
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spelling pubmed-46266892015-11-12 Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity Mori, Shogo Williams, Howard Cagle, Davey Karanovich, Kristopher Horgen, F. David Smith, Roger Watanabe, Coran M. H. Mar Drugs Article A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue. MDPI 2015-10-09 /pmc/articles/PMC4626689/ /pubmed/26473885 http://dx.doi.org/10.3390/md13106274 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mori, Shogo
Williams, Howard
Cagle, Davey
Karanovich, Kristopher
Horgen, F. David
Smith, Roger
Watanabe, Coran M. H.
Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title_full Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title_fullStr Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title_full_unstemmed Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title_short Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title_sort macrolactone nuiapolide, isolated from a hawaiian marine cyanobacterium, exhibits anti-chemotactic activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626689/
https://www.ncbi.nlm.nih.gov/pubmed/26473885
http://dx.doi.org/10.3390/md13106274
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