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Cell Death Inducing Microbial Protein Phosphatase Inhibitors—Mechanisms of Action

Okadaic acid (OA) and microcystin (MC) as well as several other microbial toxins like nodularin and calyculinA are known as tumor promoters as well as inducers of apoptotic cell death. Their intracellular targets are the major serine/threonine protein phosphatases. This review summarizes mechanisms...

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Detalles Bibliográficos
Autores principales: Kleppe, Rune, Herfindal, Lars, Døskeland, Stein Ove
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626703/
https://www.ncbi.nlm.nih.gov/pubmed/26506362
http://dx.doi.org/10.3390/md13106505