Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development

Background: Targeted toxins require multiple treatments and therefore must be deimmunized. We report a method of protein deimmunization based on the point mutation of highly hydrophilic R, K, D, E, and Q amino acids on the molecular surface of truncated diphtheria-toxin (DT390). Methods: Based on th...

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Detalles Bibliográficos
Autores principales: Schmohl, Joerg U., Todhunter, Deborah, Oh, Seung, Vallera, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626721/
https://www.ncbi.nlm.nih.gov/pubmed/26473923
http://dx.doi.org/10.3390/toxins7104067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626721/
https://www.ncbi.nlm.nih.gov/pubmed/26473923
http://dx.doi.org/10.3390/toxins7104067

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