Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme–Ligand Promiscuity Revealed at the Atomistic Level

[Image: see text] Glutamate racemase (GR) catalyzes the cofactor independent stereoinversion of l- to d-glutamate for biosynthesis of bacterial cell walls. Because of its essential nature, this enzyme is under intense scrutiny as a drug target for the design of novel antimicrobial agents. However, t...

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Detalles Bibliográficos
Autores principales: Dean, Sondra F., Whalen, Katie L., Spies, M. Ashley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626791/
https://www.ncbi.nlm.nih.gov/pubmed/26539562
http://dx.doi.org/10.1021/acscentsci.5b00211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626791/
https://www.ncbi.nlm.nih.gov/pubmed/26539562
http://dx.doi.org/10.1021/acscentsci.5b00211

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