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Retroactive modulation of spike timing-dependent plasticity by dopamine

Most reinforcement learning models assume that the reward signal arrives after the activity that led to the reward, placing constraints on the possible underlying cellular mechanisms. Here we show that dopamine, a positive reinforcement signal, can retroactively convert hippocampal timing-dependent...

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Detalles Bibliográficos
Autores principales: Brzosko, Zuzanna, Schultz, Wolfram, Paulsen, Ole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626806/
https://www.ncbi.nlm.nih.gov/pubmed/26516682
http://dx.doi.org/10.7554/eLife.09685