Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function

Corticospinal motor neurons (CSMN) receive, integrate, and relay cerebral cortex's input toward spinal targets to initiate and modulate voluntary movement. CSMN degeneration is central for numerous motor neuron disorders and neurodegenerative diseases. Previously, 5 patients with mutations in t...

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Detalles Bibliográficos
Autores principales: Jara, Javier H., Genç, Barış, Cox, Gregory A., Bohn, Martha C., Roos, Raymond P., Macklis, Jeffrey D., Ulupınar, Emel, Özdinler, P. Hande
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626833/
https://www.ncbi.nlm.nih.gov/pubmed/25596590
http://dx.doi.org/10.1093/cercor/bhu318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626833/
https://www.ncbi.nlm.nih.gov/pubmed/25596590
http://dx.doi.org/10.1093/cercor/bhu318

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