Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism

Cyclophilin D (CypD) is a mitochondrial matrix protein implicated in cell death, but a potential role in bioenergetics is not understood. Here, we show that loss or depletion of CypD in cell lines and mice induces defects in mitochondrial bioenergetics due to impaired fatty acid β-oxidation. In turn...

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Detalles Bibliográficos
Autores principales: Tavecchio, Michele, Lisanti, Sofia, Bennett, Michael J., Languino, Lucia R., Altieri, Dario C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626838/
https://www.ncbi.nlm.nih.gov/pubmed/26515038
http://dx.doi.org/10.1038/srep15981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626838/
https://www.ncbi.nlm.nih.gov/pubmed/26515038
http://dx.doi.org/10.1038/srep15981

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