Cargando…

Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo

Mediator is a large multiprotein complex conserved in all eukaryotes, which has a crucial coregulator function in transcription by RNA polymerase II (Pol II). However, the molecular mechanisms of its action in vivo remain to be understood. Med17 is an essential and central component of the Mediator...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eyboulet, Fanny, Wydau-Dematteis, Sandra, Eychenne, Thomas, Alibert, Olivier, Neil, Helen, Boschiero, Claire, Nevers, Marie-Claire, Volland, Hervé, Cornu, David, Redeker, Virginie, Werner, Michel, Soutourina, Julie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627066/ https://www.ncbi.nlm.nih.gov/pubmed/26240385 http://dx.doi.org/10.1093/nar/gkv782

Ejemplares similares

Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture
por: Eychenne, Thomas, et al.
Publicado: (2016)

Single molecule microscopy reveals mechanistic insight into RNA polymerase II preinitiation complex assembly and transcriptional activity
por: Horn, Abigail E., et al.
Publicado: (2016)

Functional interplay between Mediator and RNA polymerase II in Rad2/XPG loading to the chromatin
por: Georges, Adrien, et al.
Publicado: (2019)

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating P(i) release and conformational transitions of the preinitiation complex
por: Saini, Adesh K., et al.
Publicado: (2014)

Developmentally regulated higher-order chromatin interactions orchestrate B cell fate commitment
por: Boya, Ravi, et al.
Publicado: (2017)

Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts
por: Guan, Yiting, et al.
Publicado: (2020)

Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation
por: Kwak, Sojung, et al.
Publicado: (2018)

HrrSA orchestrates a systemic response to heme and determines prioritization of terminal cytochrome oxidase expression
por: Keppel, Marc, et al.
Publicado: (2020)

Transcription factor Sox10 orchestrates activity of a neural crest-specific enhancer in the vicinity of its gene
por: Wahlbuhl, Mandy, et al.
Publicado: (2012)

A distal enhancer maintaining Hoxa1 expression orchestrates retinoic acid-induced early ESCs differentiation
por: Su, Guangsong, et al.
Publicado: (2019)

Enhancer architecture-dependent multilayered transcriptional regulation orchestrates RA signaling-induced early lineage differentiation of ESCs
por: Su, Guangsong, et al.
Publicado: (2021)

H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis
por: Li, Zhiming, et al.
Publicado: (2022)

S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum
por: André, Gaëlle, et al.
Publicado: (2008)

MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation
por: Peng, Xianlu L., et al.
Publicado: (2017)

Zfp217 mediates m(6)A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation
por: Song, Tongxing, et al.
Publicado: (2019)

Sem1p and Ubp6p orchestrate telomeric silencing by modulating histone H2B ubiquitination and H3 acetylation
por: Qin, Song, et al.
Publicado: (2009)

SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages
por: Li, Tianlu, et al.
Publicado: (2020)

Heat shock factor 1 promotes TERRA transcription and telomere protection upon heat stress
por: Koskas, Sivan, et al.
Publicado: (2017)

The core genome (m5)C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori
por: Estibariz, Iratxe, et al.
Publicado: (2019)

Antisense transcriptional interference mediates condition-specific gene repression in budding yeast
por: Nevers, Alicia, et al.
Publicado: (2018)

WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway
por: Hsieh, Chia-Ling, et al.
Publicado: (2011)

Mutations in the CRE pocket of bacterial RNA polymerase affect multiple steps of transcription
por: Petushkov, Ivan, et al.
Publicado: (2015)

Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells
por: Mlambo, Tafadzwa, et al.
Publicado: (2018)

Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich’s ataxia
por: Kim, Eunah, et al.
Publicado: (2011)

Mediator links transcription and DNA repair by facilitating Rad2/XPG recruitment
por: Eyboulet, Fanny, et al.
Publicado: (2013)

Condensin extrudes DNA loops in steps up to hundreds of base pairs that are generated by ATP binding events
por: Ryu, Je-Kyung, et al.
Publicado: (2021)

Two-step interrogation then recognition of DNA binding site by Integration Host Factor: an architectural DNA-bending protein
por: Velmurugu, Yogambigai, et al.
Publicado: (2018)

RNA secondary structures regulate three steps of Rho-dependent transcription termination within a bacterial mRNA leader
por: Kriner, Michelle A., et al.
Publicado: (2017)

Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements
por: Taylor, Jennifer M., et al.
Publicado: (2008)

Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation
por: Hubé, Florent, et al.
Publicado: (2011)

Transcriptional complexity and roles of Fra-1/AP-1 at the uPA/Plau locus in aggressive breast cancer
por: Moquet-Torcy, Gabriel, et al.
Publicado: (2014)

Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase
por: Ferri, Federica, et al.
Publicado: (2009)

Regulation of alternative polyadenylation in the yeast Saccharomyces cerevisiae by histone H3K4 and H3K36 methyltransferases
por: Kaczmarek Michaels, Katarzyna, et al.
Publicado: (2020)

The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus
por: Rochat, Tatiana, et al.
Publicado: (2018)

The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression
por: Nouaille, Sébastien, et al.
Publicado: (2017)

Chromatin opening ability of pioneer factor Pax7 depends on unique isoform and C-terminal domain
por: Bascunana, Virginie, et al.
Publicado: (2023)

Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells
por: Miotto, Benoit, et al.
Publicado: (2018)

ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells
por: Roper, Stephen J., et al.
Publicado: (2014)

Epstein–Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation
por: Hernando, Henar, et al.
Publicado: (2014)

Species-specific regulation of XIST by the JPX/FTX orthologs
por: Rosspopoff, Olga, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_u42lv56vbg587t78ds336ledtm