Topoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter

DNA polymerases incorporate ribonucleoside monophosphates (rNMPs) into genomic DNA at a low level and such rNMPs are efficiently removed in an error-free manner by ribonuclease (RNase) H2. In the absence of RNase H2 in budding yeast, persistent rNMPs give rise to short deletions via a mutagenic proc...

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Detalles Bibliográficos
Autores principales: Cho, Jang-Eun, Kim, Nayun, Jinks-Robertson, Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627074/
https://www.ncbi.nlm.nih.gov/pubmed/26271994
http://dx.doi.org/10.1093/nar/gkv824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627074/
https://www.ncbi.nlm.nih.gov/pubmed/26271994
http://dx.doi.org/10.1093/nar/gkv824

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