Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability

The mutational pattern for the TP53 tumour suppressor gene in lung tumours differs to other cancer types by having a higher frequency of G:C>T:A transversions. The aetiology of this differing mutation pattern is still unknown. Benzo[a]pyrene,diol epoxide (BPDE) is a potent cigarette smoke carcino...

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Detalles Bibliográficos
Autores principales: Menzies, Georgina E., Reed, Simon H., Brancale, Andrea, Lewis, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627081/
https://www.ncbi.nlm.nih.gov/pubmed/26400171
http://dx.doi.org/10.1093/nar/gkv910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627081/
https://www.ncbi.nlm.nih.gov/pubmed/26400171
http://dx.doi.org/10.1093/nar/gkv910

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