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Searching target sites on DNA by proteins: Role of DNA dynamics under confinement

DNA-binding proteins (DBPs) rapidly search and specifically bind to their target sites on genomic DNA in order to trigger many cellular regulatory processes. It has been suggested that the facilitation of search dynamics is achieved by combining 3D diffusion with one-dimensional sliding and hopping...

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Detalles Bibliográficos
Autores principales: Mondal, Anupam, Bhattacherjee, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627088/
https://www.ncbi.nlm.nih.gov/pubmed/26400158
http://dx.doi.org/10.1093/nar/gkv931