Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme

The human APOBEC3A and APOBEC3B genes (A3A and A3B) encode DNA mutator enzymes that deaminate cytidine and 5-methylcytidine residues in single-stranded DNA (ssDNA). They are important sources of mutations in many cancer genomes which show a preponderance of CG->TA transitions. Although both enzym...

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Detalles Bibliográficos
Autores principales: Caval, Vincent, Bouzidi, Mohamed S., Suspène, Rodolphe, Laude, Hélène, Dumargne, Marie-Charlotte, Bashamboo, Anu, Krey, Thomas, Vartanian, Jean-Pierre, Wain-Hobson, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627089/
https://www.ncbi.nlm.nih.gov/pubmed/26384561
http://dx.doi.org/10.1093/nar/gkv935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627089/
https://www.ncbi.nlm.nih.gov/pubmed/26384561
http://dx.doi.org/10.1093/nar/gkv935

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