Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers

The in vivo potency of antisense oligonucleotides (ASO) has been significantly increased by reducing their length to 8–15 nucleotides and by the incorporation of high affinity RNA binders such as 2′, 4′-bridged nucleic acids (also known as locked nucleic acid or LNA, and 2′,4′-constrained ethyl [cET...

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Detalles Bibliográficos
Autores principales: Subramanian, Romesh R., Wysk, Mark A., Ogilvie, Kathleen M., Bhat, Abhijit, Kuang, Bing, Rockel, Thomas D., Weber, Markus, Uhlmann, Eugen, Krieg, Arthur M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627098/
https://www.ncbi.nlm.nih.gov/pubmed/26446989
http://dx.doi.org/10.1093/nar/gkv992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627098/
https://www.ncbi.nlm.nih.gov/pubmed/26446989
http://dx.doi.org/10.1093/nar/gkv992

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