Nuclear domain ‘knock-in’ screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing

CRISPR is a genome-editing platform that makes use of the bacterially-derived endonuclease Cas9 to introduce DNA double-strand breaks at precise locations in the genome using complementary guide RNAs. We developed a nuclear domain knock-in screen, whereby the insertion of a gene encoding the green f...

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Detalles Bibliográficos
Autores principales: Pinder, Jordan, Salsman, Jayme, Dellaire, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627099/
https://www.ncbi.nlm.nih.gov/pubmed/26429972
http://dx.doi.org/10.1093/nar/gkv993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627099/
https://www.ncbi.nlm.nih.gov/pubmed/26429972
http://dx.doi.org/10.1093/nar/gkv993

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