The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells

Hepatocellular carcinoma (HCC) is one of the most common lethal human malignancies worldwide and its advanced status is frequently resistant to conventional chemotherapeutic agents and radiation. We evaluated the cytotoxic effect of the orally bioavailable dual PI3K/mTOR inhibitor, NVP-BGT226, on a...

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Detalles Bibliográficos
Autores principales: Simioni, Carolina, Cani, Alice, Martelli, Alberto M., Zauli, Giorgio, Alameen, Ayman A.M., Ultimo, Simona, Tabellini, Giovanna, McCubrey, James A., Capitani, Silvano, Neri, Luca M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627298/
https://www.ncbi.nlm.nih.gov/pubmed/26003166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627298/
https://www.ncbi.nlm.nih.gov/pubmed/26003166

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