Radiosensitization and downregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K) upon inhibition of mitogen/extracellular signal-regulated kinase (MEK) in malignant melanoma cells

BACKGROUND: Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an important cofactor in the p53-mediated DNA damage response pathway upon ionizing radiation (IR) and exerts anti-apoptotic effects also independent of p53 pathway activation. Furthermore, hnRNP K is overexpressed in various neoplas...

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Detalles Bibliográficos
Autores principales: Eder, Stefan, Lamkowski, Andreas, Priller, Markus, Port, Matthias, Steinestel, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627300/
https://www.ncbi.nlm.nih.gov/pubmed/26136337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627300/
https://www.ncbi.nlm.nih.gov/pubmed/26136337

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