Mitochondrial p53 phosphorylation induces Bak-mediated and caspase-independent cell death

Chemoresistance in cancer has previously been attributed to gene mutations or deficiency. Caspase mutations or Bax deficiency can lead to resistance to cancer drugs. We recently demonstrated that Bak initiates a caspase/Bax-independent cell death pathway. We show that Plumbagin (PL) (5-hydroxy-2-met...

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Detalles Bibliográficos
Autores principales: Wang, Jinjing, Guo, Wenhao, Zhou, Hang, Luo, Na, Nie, Chunlai, Zhao, Xinyu, Yuan, Zhu, Liu, Xinyu, Wei, Yuquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627301/
https://www.ncbi.nlm.nih.gov/pubmed/25980443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627301/
https://www.ncbi.nlm.nih.gov/pubmed/25980443

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