Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma

Transmembrane protein 100 (TMEM100) was activated by ALK1/TGF-β signaling. We found that TMEM100 was decreased in hepatocellular carcinoma (HCC) tissues and in highly metastatic cell lines. Overexpressed of TMEM100 inhibited invasion, migration and proliferation. Low levels of TMEM100 were associate...

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Autores principales: Ou, Dipeng, Yang, Hao, Hua, Dong, Xiao, Shuai, Yang, Lianyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627315/
https://www.ncbi.nlm.nih.gov/pubmed/25978032
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author Ou, Dipeng
Yang, Hao
Hua, Dong
Xiao, Shuai
Yang, Lianyue
author_facet Ou, Dipeng
Yang, Hao
Hua, Dong
Xiao, Shuai
Yang, Lianyue
author_sort Ou, Dipeng
collection PubMed
description Transmembrane protein 100 (TMEM100) was activated by ALK1/TGF-β signaling. We found that TMEM100 was decreased in hepatocellular carcinoma (HCC) tissues and in highly metastatic cell lines. Overexpressed of TMEM100 inhibited invasion, migration and proliferation. Low levels of TMEM100 were associated with cirrhosis, tumor size, Tumor nodule number, TNM stage, BCLC stage, Edmondson-Steiner Stage and vein invasion. Furthermore, TMEM100 was an independent risk factor for overall survival (P = 0.03) and disease-free survival (P = 0.019). The current findings suggest that TMEM100 functions as a tumor suppressor in HCC metastasis and proliferation.
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spelling pubmed-46273152015-12-02 Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma Ou, Dipeng Yang, Hao Hua, Dong Xiao, Shuai Yang, Lianyue Oncotarget Research Paper Transmembrane protein 100 (TMEM100) was activated by ALK1/TGF-β signaling. We found that TMEM100 was decreased in hepatocellular carcinoma (HCC) tissues and in highly metastatic cell lines. Overexpressed of TMEM100 inhibited invasion, migration and proliferation. Low levels of TMEM100 were associated with cirrhosis, tumor size, Tumor nodule number, TNM stage, BCLC stage, Edmondson-Steiner Stage and vein invasion. Furthermore, TMEM100 was an independent risk factor for overall survival (P = 0.03) and disease-free survival (P = 0.019). The current findings suggest that TMEM100 functions as a tumor suppressor in HCC metastasis and proliferation. Impact Journals LLC 2015-04-29 /pmc/articles/PMC4627315/ /pubmed/25978032 Text en Copyright: © 2015 Ou et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ou, Dipeng
Yang, Hao
Hua, Dong
Xiao, Shuai
Yang, Lianyue
Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma
title Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma
title_full Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma
title_fullStr Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma
title_full_unstemmed Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma
title_short Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma
title_sort novel roles of tmem100: inhibition metastasis and proliferation of hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627315/
https://www.ncbi.nlm.nih.gov/pubmed/25978032
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