Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status

The PKCβ inhibitor enzastaurin was tested in parental neuroblastoma and rhabdomyosarcoma cell lines, their vincristine-resistant sub-lines, primary neuroblastoma cells, ABCB1-transduced, ABCG2-transduced, and p53-depleted cells. Enzastaurin IC(50)s ranged from 3.3 to 9.5 μM in cell lines and primary...

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Detalles Bibliográficos
Autores principales: Michaelis, Martin, Rothweiler, Florian, Löschmann, Nadine, Sharifi, Mohsen, Ghafourian, Taravat, Cinatl, Jindrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627332/
https://www.ncbi.nlm.nih.gov/pubmed/25749379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627332/
https://www.ncbi.nlm.nih.gov/pubmed/25749379

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