Cargando…

Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status

The PKCβ inhibitor enzastaurin was tested in parental neuroblastoma and rhabdomyosarcoma cell lines, their vincristine-resistant sub-lines, primary neuroblastoma cells, ABCB1-transduced, ABCG2-transduced, and p53-depleted cells. Enzastaurin IC(50)s ranged from 3.3 to 9.5 μM in cell lines and primary...

Descripción completa

Detalles Bibliográficos
Autores principales:	Michaelis, Martin, Rothweiler, Florian, Löschmann, Nadine, Sharifi, Mohsen, Ghafourian, Taravat, Cinatl, Jindrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627332/ https://www.ncbi.nlm.nih.gov/pubmed/25749379

Ejemplares similares

ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance
por: Löschmann, Nadine, et al.
Publicado: (2016)

Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport
por: Michaelis, Martin, et al.
Publicado: (2016)

Aurora Kinases as Targets in Drug-Resistant Neuroblastoma Cells
por: Michaelis, Martin, et al.
Publicado: (2014)

ABCG2 impairs the activity of the aurora kinase inhibitor tozasertib but not of alisertib
por: Michaelis, Martin, et al.
Publicado: (2015)

Resistance to nanoparticle albumin-bound paclitaxel is mediated by ABCB1 in urothelial cancer cells
por: Vallo, Stefan, et al.
Publicado: (2017)

Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents
por: Michaelis, M, et al.
Publicado: (2012)

Inhibition of Glycogen Synthase Kinase 3 (GSK3) Increases the Cytotoxicity of Enzastaurin
por: Rovedo, Mark, et al.
Publicado: (2011)

Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach
por: Sarin, Navin, et al.
Publicado: (2018)

Correlation of inflammatory and proangiogenic cytokines from undiluted vitreous samples with spectral domain OCT scans, in untreated branch retinal vein occlusion
por: Pfister, Marcel, et al.
Publicado: (2013)

The Protein Kinase C Inhibitor Enzastaurin Exhibits Antitumor Activity against Uveal Melanoma
por: Wu, Xinqi, et al.
Publicado: (2012)

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells
por: Michaelis, M, et al.
Publicado: (2011)

BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells
por: Das, Chandan Kanta, et al.
Publicado: (2018)

Association between acquired resistance to PLX4032 (vemurafenib) and ATP-binding cassette transporter expression
por: Michaelis, Martin, et al.
Publicado: (2014)

Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen
por: Michaelis, Martin, et al.
Publicado: (2015)

Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs
por: Gelardi, T, et al.
Publicado: (2008)

Enzastaurin inhibits invasion and metastasis in lung cancer by diverse molecules
por: Körner, A, et al.
Publicado: (2010)

YM155-Adapted Cancer Cell Lines Reveal Drug-Induced Heterogeneity and Enable the Identification of Biomarker Candidates for the Acquired Resistance Setting
por: Michaelis, Martin, et al.
Publicado: (2020)

Testing of the Survivin Suppressant YM155 in a Large Panel of Drug-Resistant Neuroblastoma Cell Lines
por: Michaelis, Martin, et al.
Publicado: (2020)

Increased HRD score in cisplatin resistant penile cancer cells
por: Winkelmann, Ria, et al.
Publicado: (2022)

Therapeutic natural compounds Enzastaurin and Palbociclib inhibit MASTL kinase activity preventing breast cancer cell proliferation
por: Polisety, Aneesha, et al.
Publicado: (2022)

Drug-Resistant Urothelial Cancer Cell Lines Display Diverse Sensitivity Profiles to Potential Second-Line Therapeutics()()
por: Vallo, Stefan, et al.
Publicado: (2015)

In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib
por: Redaelli, Sara, et al.
Publicado: (2015)

Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G(2)/M cell cycle arrest
por: Sarin, Navin, et al.
Publicado: (2017)

The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats
por: Willeman, Mari N., et al.
Publicado: (2018)

The Thrombopoietin Receptor Agonist Eltrombopag Inhibits Human Cytomegalovirus Replication Via Iron Chelation
por: Vogel, Jens-Uwe, et al.
Publicado: (2019)

Molecular Characterization of Auxin Efflux Carrier- ABCB1 in hexaploid wheat
por: Mohan, Amita, et al.
Publicado: (2019)

Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules
por: Shimokawa, T, et al.
Publicado: (2012)

Phase I study of enzastaurin and bevacizumab in patients with advanced cancer: safety, efficacy and pharmacokinetics
por: Nwankwo, Nwabundo, et al.
Publicado: (2012)

Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance
por: Voges, Yvonne, et al.
Publicado: (2016)

Effects of flavonoid-induced oxidative stress on anti-H5N1 influenza a virus activity exerted by baicalein and biochanin A
por: Michaelis, Martin, et al.
Publicado: (2014)

Investigation of the influence of EPs(®) 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses
por: Michaelis, Martin, et al.
Publicado: (2011)

Drug-adapted cancer cell lines as preclinical models of acquired resistance
por: Michaelis, Martin, et al.
Publicado: (2019)

Critical Role of the Maternal Immune System in the Pathogenesis of Autism Spectrum Disorder
por: Ravaccia, Davide, et al.
Publicado: (2020)

Dasatinib enhances tumor growth in gemcitabine-resistant orthotopic bladder cancer xenografts
por: Vallo, Stefan, et al.
Publicado: (2016)

Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine
por: Isono, Makoto, et al.
Publicado: (2017)

SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine
por: Rothenburger, Tamara, et al.
Publicado: (2020)

Intact-Cell MALDI-ToF Mass Spectrometry for the Authentication of Drug-Adapted Cancer Cell Lines
por: Povey, Jane F., et al.
Publicado: (2019)

Molecular Mechanisms for Biliary Phospholipid and Drug Efflux Mediated by ABCB4 and Bile Salts
por: Morita, Shin-ya, et al.
Publicado: (2014)

Systems approaches reveal that ABCB and PIN proteins mediate co-dependent auxin efflux
por: Mellor, Nathan L, et al.
Publicado: (2022)

A phase I dose-escalation and pharmacokinetic study of enzastaurin and erlotinib in patients with advanced solid tumors
por: Padda, Sukhmani K., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_chm3dg339btb3ncamfq7f8279v