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Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation

Epithelial-mesenchymal transition (EMT) was reported to be involved in the activation of hepatic stellate cells (HSCs), contributing to the development of liver fibrosis. Epithelial-mesenchymal transition can be promoted by the Hedgehog (Hh) pathway. Patched1 (PTCH1), a negative regulatory factor of...

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Detalles Bibliográficos
Autores principales: Yu, Fujun, Lu, Zhongqiu, Chen, Bicheng, Wu, Xiaoli, Dong, Peihong, Zheng, Jianjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627567/
https://www.ncbi.nlm.nih.gov/pubmed/26257392
http://dx.doi.org/10.1111/jcmm.12655