Cell populations can use aneuploidy to survive telomerase insufficiency

Telomerase maintains ends of eukaryotic chromosomes, telomeres. Telomerase loss results in replicative senescence and a switch to recombination-dependent telomere maintenance. Telomerase insufficiency in humans leads to telomere syndromes associated with premature ageing and cancer predisposition. H...

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Detalles Bibliográficos
Autores principales: Millet, Caroline, Ausiannikava, Darya, Le Bihan, Thierry, Granneman, Sander, Makovets, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627575/
https://www.ncbi.nlm.nih.gov/pubmed/26489519
http://dx.doi.org/10.1038/ncomms9664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627575/
https://www.ncbi.nlm.nih.gov/pubmed/26489519
http://dx.doi.org/10.1038/ncomms9664

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