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Cell populations can use aneuploidy to survive telomerase insufficiency
Telomerase maintains ends of eukaryotic chromosomes, telomeres. Telomerase loss results in replicative senescence and a switch to recombination-dependent telomere maintenance. Telomerase insufficiency in humans leads to telomere syndromes associated with premature ageing and cancer predisposition. H...
Autores principales: | Millet, Caroline, Ausiannikava, Darya, Le Bihan, Thierry, Granneman, Sander, Makovets, Svetlana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627575/ https://www.ncbi.nlm.nih.gov/pubmed/26489519 http://dx.doi.org/10.1038/ncomms9664 |
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