Dual Mutation Events in the Haemagglutinin-Esterase and Fusion Protein from an Infectious Salmon Anaemia Virus HPR0 Genotype Promote Viral Fusion and Activation by an Ubiquitous Host Protease

In Infectious salmon anaemia virus (ISAV), deletions in the highly polymorphic region (HPR) in the near membrane domain of the haemagglutinin-esterase (HE) stalk, influence viral fusion. It is suspected that selected mutations in the associated Fusion (F) protein may also be important in regulating...

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Detalles Bibliográficos
Autores principales: Fourrier, Mickael, Lester, Katherine, Markussen, Turhan, Falk, Knut, Secombes, Christopher J., McBeath, Alastair, Collet, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627773/
https://www.ncbi.nlm.nih.gov/pubmed/26517828
http://dx.doi.org/10.1371/journal.pone.0142020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627773/
https://www.ncbi.nlm.nih.gov/pubmed/26517828
http://dx.doi.org/10.1371/journal.pone.0142020

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